Professor Ross Coppel

VIIN Member

Victorian Bioinformatics Consortium
Monash University
+61399054822
ross.coppel@med.monash.edu.au

Research Activities:

Studies on various aspects of malaria biology; focussing on asexual stages including proteins of the merozoite surface, the rhoptry and the molecular motor.
Vaccine studies including improved methods of delivery, DNA vaccination, oral immunization, transgenic plants, viral delivery. GMP production of recombinant proteins for human clinical trials.
Studies on mycobacteria including M. avium, M. smegmatis. Pathways of bacterial cell wall synthesis, host-pathogen biology including mycobacteria in macrophages, identification of genes involved in resisting phagocytosis.

Techniques/Expertise:

Malaria gene knockout
Malaria parasite culture
Mouse models of malaria infection
Molecular biology
Protein expression
Immunochemistry
Immunofluorescence
Protein-protein interactions
Microarrays
Bacterial genetics
TLC
Cell wall analysis
Sequencing
Bioinformatics
Serology
ELISA
Malaria growth inhibition assays

Collaborations:

Malaria NHMRC program
Magda Plebanski, Burnet Institute at Austin
Mark von Itzstein Griffith University
Brian Cooke, Monash University
Mohan Narla, New York Blood centre
Eric Gershwin, University of California, Davis
Laurie Bannister, London
ARC Centre of Excellence in structural and functional microbial genetics

Animal Disease Models:

Malaria in mice; Plasmodium chabaudi and Plasmodium yoelii

Genetically Modified Animals:

4.1 KO mice
CD36 KO mice

Lab Group Personnel:

Postdoctoral Scientists:

Paul Crellin
Assunta Pelosi
David Lea Smith
Casilda Black
Lina Wang
Harini De Silva
Svetozar Kovacevic
Khosse Mitri

Research Assistants:

Daniel Drieberg
Georgina Sallman
Valentina Dublevic
Farida Motorina-Valeeva

Also PhD and Honours students