Dr Jian Li

VIIN Member

Facility for Anti-infective Drug Development and Innovation
Victorian College of Pharmacy
+61399039702
jian.li@pharm.monash.edu.au

Research Activities:

Pharmacokinetics and pharmacodynamics of polymyxins against multidrug-resistant ‘superbugs’, in particular Pseudomonas aeruginosa and Acinetobacter baumannii (NHMRC funded projects, NIH grant application)
Chemotherapy for infections in patients with cystic fibrosis
Novel anti-pathogenic agents
Integration of pharmacokinetic and pharmacodynamic principles to assist in antimicrobial development, to reduce resistance development and to optimize efficacy in the clinical use of antimicrobial agents
Discovery of novel antimicrobial agents against bacterial ‘superbugs’
Combination of antimicrobial agents
Lead optimisation of new antimicrobial entities

Techniques/Expertise:

Susceptibility testing including: minimum inhibitory and bactericidal concentrations; fractional inhibition concentrations (for combinations); population analysis profiles
Time-kill experiments and post-antibiotic effect experiments (in vitro and in vivo )
in vitro Pharmacokinetic/Pharmacodynamic (PK/PD) infection model
in vitro biofilm model
Animal infection models (mouse thigh and mouse lung)
Quantitative analysis of drugs in biological fluids (using HPLC and bioassays)
Pharmacokinetics of antimicrobials in small animals, including hepatic and renal handling of drugs and metabolites
Discovery and purification of novel antimicrobial agents from natural products

Collaborations:

Professor John Turnidge and Associate Professor Kingsley Coulthard (Women’s and Children’s Hospital)
Associate Professor David Paterson (University of Pittsburg, USA)
Professor Alan Forrest (State University of New York at Buffalo, USA)
Associate Professor Denis Spelman (Alfred Hospital)
Professor Jeff Lipman (University of Queensland)
Dr Peter Ward (Austin Health)
Associate Professor Robert Milne (Sansom Institute, University of South Australia)
Dr Cynthia Whitchurch (Department of Microbiology, Monash University)
Dr Deborah Middleton (Australian Animal Health Laboratory, CSIRO)
Drs Ian Larson and Ben Boyd (Department of Pharmaceutics, Monash University)
Dr Alexandre Prehn Zavascki (Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Brazil)
Dr John Mohr (University of Texas Medical School, USA)

Animal Disease Models:

Mouse thigh infection model
Mouse lung infection model

Existing Websites:

http://www.vcp.monash.edu.au/departments/pharmpract/staff/jli.html

Lab Group Personnel:

In Professor Roger Nation’s research group
Ms Roxanne Owen
Mr Phillip Bergen
Ms Lauren Boak
Mr Robin Tan
Mr Rajesh Dudhani
Ms Stephanie Wallace