Dr Ashley Mansell

VIIN Member

Centre for Functional Genomics and Human Disease
Monash Institute of Medical Research
+61395947215
ashley.mansell@med.monash.edu.au

Research Activities:

Toll-like receptor based research investigating:
Signal transduction pathways initiated upon recognition of both pathogen and endogenous TLR ligands
The negative regulation of these pathways to prevent chronic inflammation
Pathogen immunomodulation of these pathways/receptors

Techniques/Expertise:

Activation of NF-kB by various means
Cell biology
TLR screening

Collaborations:

Luke O’Neill, Trinity College Dublin
Katherine Fitzgerald, University of Massachusetts
Doug Hilton, Walter and Eliza Hall Institute
Steve Gerondakis, Walter and Eliza Hall Institute
Grant Drummond, Monash University
Richard Ferrero, Monash University

Animal Disease Models:

Septic Shock

Genetically Modified Animals:

Mal-/-, SOCS-1-/-, IFNγ-/-, IRF3-/-, MyD88-/-

Existing Websites:

www.tlroz.org

Lab Group Personnel:

Mr Brett Verstak (PhD Student)
Ms Tali Lang (Research Assistant)
Ms Kim Mosse (Honours Student)